Km, or the Michaelis constant, is a measure in enzymology that represents the substrate concentration at which an enzyme operates at half its maximum velocity. It indicates the affinity of the enzyme for its substrate; a lower Km suggests higher affinity, while a higher Km indicates lower affinity.

About Km
Km was introduced in 1913 by Leonor Michaelis and Maud Menten. They developed the concept to describe the kinetics of enzyme-catalyzed reactions, aiming to quantify the relationship between substrate concentration and reaction rate. Their work laid the foundation for modern enzymology and provided a crucial tool for understanding enzyme behavior.
Strengths of Km include its ability to provide insights into enzyme-substrate affinity and its foundational role in enzymology. Weaknesses involve potential inaccuracies in complex systems where multiple substrates or inhibitors are present. Competitors include other kinetic parameters like kcat/Km, which offers a more comprehensive measure of catalytic efficiency.
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How to hire a Km expert
A Km expert must possess strong skills in enzymology, proficiency in kinetic data analysis, and experience with enzyme assays. They should also be adept in using software tools for curve fitting and statistical analysis, and have a solid understanding of biochemical principles governing enzyme-substrate interactions.

João L.
Skills
A Software Engineer proficient in developing robust and scalable APIs using Node.js with TypeScript, along with frameworks like Express and Nest, tailored for web applications in high-performance and critical environments managing sensitive data for millions of users. Expertise includes delivering solutions for telemedicine within the Unified Health System for the health department, and optimization and management solutions for major steel companies in Brazil.
Proficient in a range of technologies including JavaScript, TypeScript, Node.js, and Golang; cloud services such as AWS, GCP, and Azure; and tools like Docker, Kubernetes, Kafka, and RabbitMQ. Utilizes microservices architecture, adheres to Clean Architecture principles, SOLID principles, and design patterns. Database management skills encompass MongoDB, PostgreSQL, and MySQL, with a robust approach to unit testing.
A dedicated professional with a passion for technology and continuous learning, aiming to positively impact lives through innovative solutions. Committed to improving quality of life by selecting optimal problem-solving strategies that consider cost, well-being, time constraints, and appropriate technology use.

André K.
Skills
Systems development professional with extensive experience in creating innovative and efficient solutions. Expertise encompasses full-stack development with proficiency in both front-end and back-end skills using languages such as PHP, Dart, JavaScript, and Kotlin. Experienced in software architecture, database design, and API implementation, with a significant background in participating in agile projects to deliver high-quality software within challenging deadlines.
Possesses deep knowledge of frameworks such as Laravel (PHP) and Flutter (Dart) and stays current with industry trends and technologies. Proficient in DevOps practices, continuous integration, and version control using Git. Employs a user-centric approach and strong problem-solving capabilities, facilitating effective collaboration within multidisciplinary teams to ensure products meet customer expectations. Continuously seeks challenges that enable skill expansion and contribute to the development of innovative and high-performance systems.

Denilson S.
Skills
Master of Science in Computer Engineering from the Polytechnic School of Engineering at USP, with a bachelor's degree in Computer Science. Over twenty-eight years of experience, including twelve years specializing in C/C++ development. Demonstrated expertise in software development for the financial sector, military applications, and electronic gaming. Proficient in a range of programming languages, including C/C++, assembly, Python, R, Fortran, and Prolog. Skilled in utilizing development environments such as Visual Studio, Eclipse, NetBeans, and Kdeveloper. Experienced in SCADA system development and concurrent software development using Threads.
Proficient in database management systems, including HDF5, SQL Server, Oracle, MySQL, and PostgreSQL. Familiar with various operating systems, such as Linux, AIX, Solaris, HP-UX, and Windows. Adept at using libraries including libXML, Pthreads, PracticalSocket, Glib, Qt, and FFTW, as well as eTerra-Habitat. Expertise in software development with sockets and interprocess communication through message queues and shared memory.
Specializes in parallel programming with MPI, openMP, CUDA, openCL, and Intel Xeon PHI. Experienced with Qt Designer and knowledgeable about the ISO 8583 standard.

Felipe D.
Skills
Possui conhecimentos em sistemas de controle de versão git e plataformas como GitHub e GitLab. Competência no desenvolvimento com linguagens de programação e frameworks, incluindo JavaScript, TypeScript, Node.js, Express, React, Next.js e React Native. Experiência com bancos de dados relacionais e não relacionais, como PostgreSQL, MySQL, Firebase e MongoDB.

Ramon F.
Skills
Full-stack developer with expertise in creating and managing web platforms, websites, and mobile applications. Demonstrates strong communication skills and consistently pursues opportunities for learning and embracing new challenges.

Gustavo B.
Skills
A Computer Science student at PUC-Rio specializing in mobile and web development. Known for a strong dedication to work, exceptional organizational skills, and a continuous commitment to expanding knowledge and expertise in the field.

Eduardo L.
Skills
Web Developer with extensive experience since 2016, primarily specializing as a Full-Stack Software Engineer. Proficient in developing applications using various technologies, including Java 8, C#, ASP.NET MVC, .NET Core, AngularJS, Angular (version 7+), Aurelia, KnockoutJS, and React.

Thiago A.
Skills
Dynamic professional with a strong willingness to learn and teach, possessing excellent communication and interpersonal skills. Demonstrates a keen ability to work within and contribute to team development.
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